The best Side of cees dekker
The best Side of cees dekker
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‘Yes, that is certainly about right. I seek out a Actual physical knowledge of Organic systems within a base-up way. I do think you may distinguish 3 strains of study in my group at the moment. The first worries chromosome composition: how do you obtain a metre-very long DNA polymer folded and organised in this kind of microscopic cell? We've designed visualisation procedures that permit us to study how, one example is, SMC proteins loop DNA (online video on Youtube) to be able to Construct up chromosomes.
Human Rad51 filaments on double- and single-stranded DNA: correlating common and irregular forms with recombination operate.
Multicolor imaging of the bacterial nucleoid and mobile division proteins with blue, orange, and in close proximity to-infrared fluorescent proteins
Sculpting nano-electrodes that has a transmission electron beam for electrical and geometrical characterization of nanoparticles.
That is a aspiration of mine and we established to work that has a scrumptious dose of naivety. This is certainly something which will most likely generate breathtaking ends in the longer phrase, but that doesn't matter. You should not only want to operate over the concerns of tomorrow, but in addition over the concerns on the working day after tomorrow.’
Microbiology has only existed for a century, given that we started to examine micro-organisms additional severely. I assumed nanobiology was an correct time period, because all molecular biological relevant interactions take place with the nanoscale: a protein is some nanometres in sizing, DNA is two nm thick.’
All parameters were being exactly the same for each panel In this particular movie, aside from the Original placement of the 6hb rod (shown in blue) around the nanopore. Simulations that terminated early on account of translocation with the rod in the pore are marked by a gray background.
Studying DNA loop extrusion by SMC proteins for chromosome architecture with one-molecule assays.
‘Sure, I have an understanding of folks were being shocked at enough time. At the conclusion of the nineties, when I was in my forties, I used to be Professor of Molecular Electronics and I've to admit that it experienced turn into a bit bored, I didn’t find out A great deal any more. The sector went more into the appliance aspect, how you could integrate nanotubes into Digital circuits.
Right now, we also recognized that it should be possible to use a single semiconducting carbon nanotube to make a transistor — and we set out to really make it. We stretched unique semiconducting nanotubes throughout metallic electrodes and applied the fundamental silicon substrate being a gate electrode, creating The fundamental 3-terminal layout of the industry-influence transistor (Fig.
Considering that 2000 he moved to single-molecule biophysics and nanobiology, with investigate from scientific studies of DNA loop extrusion and supercoiling to DNA translocation through nanopores. Extra just lately his study has centered on studying chromatin composition and cell division with micro organism on chip, whilst he is usually trying to finally Construct artificial cells from the bottom up.
Cees Dekker is Distinguished College Professor at TU Delft. Properly trained to be a physicist, he pioneered nanotechnology with many discoveries on carbon nanotubes within the 1990s. Because 2000, he moved to single-molecule biophysics and nanobiology. His present study focuses on (i) nanopores for protein sequencing; (ii) chromosome composition, in particular SMC motor protein; and (iii) developing a dwelling artificial cell from lifeless molecules. Dekker is surely an elected member from the KNAW and fellow towards the APS and https://www.ceesdekker.net also the IOP.
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‘I am driven by surprise and issues. On a cloth level I discover solutions in physics, but I practical experience my deepest contentment with God. That religion also drives my science and how I cope with folks.